Beisaw Lab Publications

Constanty F*, Wu B*, Wei KH, Lin IT, Dallmann J, Guenther S, Lautenschlaeger T, Priya R, Lai SL, Stainier DYR, Beisaw A. Border-zone cardiomyocytes and macrophages contribute to remodeling of the extracellular matrix to promote cardiomyocyte invasion during zebrafish cardiac regeneration. bioRxiv doi:10.1101/2024.03.12.584570 *co-first authors

Beisaw A# and Wu CC#. Cardiomyocyte maturation and its reversal during cardiac regeneration. Developmental Dynamics. 2024; 1- 20. doi:10.1002/dvdy.557. #co-corresponding authors

Collaborations

Vasudevarao MD, Posadas Pena D, Ihle M, Bongiovanni C, Maity P, Redaelli S, Happ K, Geissler D, Mohammadi HF, Rall-Scharpf M, Wu CC, Beisaw A, Scharffetter-Kochanek K, D’Uva G, Wiesmüller L, Weidinger G. BMP signaling promotes heart regeneration via alleviation of replication stress. bioRxiv doi: 10.1101/2024.05.24.595503

Hofmann C, Serafin A, Schwerdt OM, Fischer J, Sicklinger F, Younesi FS, Byrne NJ, Meyer IS, Malovrh E, Sandmann C, Jürgensen L, Kampf-Schenk V, Stroh C, Löwenthal Z, Finke D, Boileau E, Beisaw A, Bugger H, Bettel M, Stein F, Katus HA, Jakobi T, Frey N, Leuschner F, Völkers M. Transient Inhibition of Translation Improves Cardiac Function After Ischemia/Reperfusion by Attenuating the Inflammatory Response. Circulation 2024. doi:10.1161/CIRCULATIONAHA.123.067479.

Cordero J, Elsherbiny A, Wang Y, Jürgensen L, Constanty F, Guenther S, Boerries M, Heineke J, Beisaw A, Leuschner F, Hassel D, Dobreva G. Leveraging chromatin state transitions for the identification of regulatory networks orchestrating heart regeneration. Nucleic Acids Research. 2024.

Prior Publications

Fukuda R, Marin-Juez R, El Sammak H, Beisaw A, Konzer A, Bhagwat AM, Graumann J, Stainier DYR. Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish. EMBO Reports. 2020; 21: e49752.

Beisaw A#, Kuenne C, Guenther S, Dallmann J, Wu CC, Bentsen M, Looso M, Stainier DYR#. AP-1 contributes to chromatin accessibility to promote sarcomere disassembly and cardiomyocyte protrusion during zebrafish heart regeneration. Circulation Research. 2020; 126: 1760-1778. #co-corresponding authors

Fukuda R, Gunawan F, Ramadass R, Beisaw A, Konzer A, Mullapudi ST, Gentile A, Maischein HM, Graumann J, Stainier DYR. Mechanical forces regulate cardiomyocyte maturation via the Vinculin-Slingshot1-Cofilin axis. Developmental Cell. 2019; 51: 62-77.

Ritter N, Ali T, Kopitchinski N, Schuster P, Beisaw A, Hendrix D, Schulz MH, Müller-McNicoll M, Dimmeler S, Grote P. The lncRNA locus Handsdown regulates cardiac gene programs and is essential for early mouse development. Developmental Cell. 2019; 50: 1-14.

Marass M*, Beisaw A*, Gerri C, Luzzani F, Fukuda N, Guenther S, Kuenne C, Reischauer S, Stainier DYR. Genome-wide strategies reveal target genes of Npas4l associated with vascular development in zebrafish. Development. 2019; 146: dev173427. *co-first authors

Beisaw A, Koch F, Tsaytler P, Schmitz SU, Melissari MT, Senft AD, Wittler L, Pennimpede T, Macura K, Herrmann BG, Grote P. BRACHYURY directs histone acetylation to target loci during mesoderm development. EMBO Reports. 2018; 19: 118-134.

Fukuda R, Gunawan F, Beisaw A, Jimenez-Amilburu V, Maischein HM, Kostin S, Kawakami K, Stainier DYR. Proteolysis regulates cardiomyocyte maturation and tissue integration. Nature Communications. 2017; 8: 14495.

Grote P, Wittler L, Hendrix D, Koch F, Waehrisch S, Beisaw A, Macura K, Blaess G, Kellis M, Werber M, Herrmann BG. The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. Developmental Cell. 2013; 24(2): 206-214.

Chalamalasetty RB, Dunty WC Jr, Biris KK, Ajima R, Iacovino M, Beisaw A, Feigenbaum L, Chapman DL, Yoon JK, Kyba M, Yamaguchi TP. The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signaling program. Nature Communications. 2011; 2: 390.

Monday SR, Beisaw A, Feng PC. Identification of Shiga toxigenic Escherichia coli seropathotypes A and B by multiplex PCR. Molecular and Cellular Probes. 2007; 21(4): 308-311.